ATP1A1 ELISA Kit for Human(Homo sapiens) | EIAab.comATP1A1 ELISA Kit for Human(Homo sapiens)

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ATP1A1 (Gene name),

Sodium/potassium-transporting ATPase subunit alpha-1 (Protein name ), AT1A1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ATP1A1;

Protein name:

Sodium/potassium-transporting ATPase subunit alpha-1(Na(+)/K(+) ATPase alpha-1 subunit);

Alternative:

Sodium pump subunit alpha-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SIK1 (By similarity). Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.

Function:

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Subcellular Location:

Cell membrane Multi-pass membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Attributes:

Sequence length:

1023

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1023:

YDEVRKLIIR | RRPGGWVEKE | TYY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000295598

SMR:

P05023

KEGG:

hsa:476

Pfam:

PF00689

MIM:

182310

UniGene:

Hs.371889

String:

P05023

Uniprot:

P05023

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570r

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570p

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96T

ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570b

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570c

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570m

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570d

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ELISA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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E12570h

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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U12570b

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

MSDS:

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CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

Cat.:

U12570r

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

Cat.:

U12570m

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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U12570d

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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U12570h

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

Cat.:

U12570p

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96T

CLIA Kit for Human Na(+)/K(+) ATPase alpha-1 subunit

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U12570c

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Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-1 subunit

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P12570Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-1 subunit

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P12570Rb-h

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Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-1 subunit

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P12570Rb-r

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Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-1 subunit

Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-1 subunit

Protein for Human Na(+)/K(+) ATPase alpha-1 subunit

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence."
Kawakami K. , Ohta T. , Nojima H. , Nagano K.
J. Biochem.100:389-397(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium."
Ruiz A. , Bhat S.P. , Bok D.
Gene155:179-184(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Retinal pigment epithelium.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
tissue: Cerebellum.
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Cervix.
tissue: Skin.
7.

"The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism."
Shull M.M. , Pugh D.G. , Lingrel J.B.
Genomics6:451-460(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61
8.

Zhang J.-S. , Yang J.X. , Fang M.W. , Lu S.D.
Submitted (1996-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-148
tissue: Placenta.
9.

"Multiple genes encode the human Na+,K+-ATPase catalytic subunit."
Shull M.M. , Lingrel J.B.
Proc. Natl. Acad. Sci. U.S.A.84:4039-4043(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-189 AND 213-244
10.

"Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization."
Chehab F.F. , Kan Y.W. , Law M.L. , Hartz J. , Kao F.T. , Blostein R.
Proc. Natl. Acad. Sci. U.S.A.84:7901-7905(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-943 (ISOFORM 1)
tissue: Placenta.
11.

"Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size."
Chicz R.M. , Urban R.G. , Lane W.S. , Gorga J.C. , Stern L.J. , Vignali D.A.A. , Strominger J.L.
Nature358:764-768(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 199-216;INTERACTION WITH HLA-DR1
12.

"The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit."
Sverdlov E.D. , Monastyrskaya G.S. , Broude N.E. , Ushkaryov Y.A. , Allikmets R.L. , Melkov A.M. , Smirnov Y.V. , Malyshev I.V. , Dulubova I.E. , Petrukhin K.E. , Gryshin A.V. , Kiyatkin N.I. , Kostina M.B. , Sverdlov V.E. , Modyanov N.N. , Ovchinnikov Y.A.
FEBS Lett.217:275-278(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-341 AND 420-444
13.

"Amino acid sequence of the 17-kilodalton fragment of the cytoplasmic region of the alpha-subunit of NA+,K+-ATPase."
Ovchinnikov Y.A. , Monastyrskaya G.S. , Arsenyan S.G. , Broude N.E. , Petrukhin K.E. , Grishin A.V. , Arzamazova N.M. , Severtsova I.V. , Modyanov N.N.
Dokl. Biochem.288:270-272(1986)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 471-619
14.

"Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle."
Hundal H.S. , Maxwell D.L. , Ahmed A. , Darakhshan F. , Mitsumoto Y. , Klip A.
Mol. Membr. Biol.11:255-262(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
15.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
16.

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
17.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-542;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
Krapivinsky G. , Krapivinsky L. , Stotz S.C. , Manasian Y. , Clapham D.E.
Proc. Natl. Acad. Sci. U.S.A.108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC35G1 AND STIM1

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